Exhibit 5.1

Wilson Sonsini Goodrich & Rosati Professional Corporation 650 Page Mill Road Palo Alto, CA 94304 o: (650) 493-9300 f: (650) 493-6811

November 10, 2022

RenovoRx, Inc.

4546 El Camino Real, Suite B1

Los Altos, CA 94022

Ladies and Gentlemen:

This opinion is furnished to you in connection with the Registration Statement on Form S-1 (the “Registration Statement”) filed by RenovoRx, Inc., a Delaware corporation (the “Company”) with the Securities and Exchange Commission (the “Commission”) in connection with the registration under the Securities Act of 1933, as amended (the “Securities Act”), of the (i) the registration of up to 2,786,995 shares of the Company’s Common Stock, $0.0001 par value per share, issuable upon the exercise of warrants (including (a) 1,879,300 shares issuable upon the exercise of outstanding IPO Warrants (as defined in the Registration Statement) (the “IPO Warrants Shares”), (b) 198,875 shares issuable upon the exercise of outstanding Underwriter Warrants (as defined in the Registration Statement) (the “Underwriter Warrants Shares”), and (c) 708,820 shares issuable upon the exercise of outstanding Note Warrants (as defined in the Registration Statement) (the “Note Warrants Shares”) and (ii) the offer and resale of up to (a) 2,786,995 shares of the Company’s Common Stock and (b) 708,820 Note Warrants by the Selling Securityholders (as defined in the Registration Statement).

The IPO Warrants Shares, Underwriter Warrants Shares and Note Warrants Shares are collectively referred to herein as the “Warrant Shares,” the Note Warrants are referred to herein as the “Warrants,” and the Warrant Shares and Warrants are collectively referred to herein as the “Securities.”

We are acting as counsel for the Company in connection with the registration of the Securities. As such counsel, we have made legal and factual examinations and inquiries as we have deemed necessary or advisable for the purpose of rendering the opinion set forth below. In rendering the opinion expressed below, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents, corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this opinion.

In addition, we have reviewed originals or copies of such corporate records of the Company, certificates of public officials, a certificate of an officer of the Company as to factual matters, and such other documents that we considered necessary or advisable for the purpose of rendering the opinions set forth below, including the form of Warrant Certificate filed as Exhibit 4.5 to the Registration Statement and the Form of Warrant Agent Agreement filed as Exhibit 4.3 to the Registration Statement. We have not independently established the facts stated therein. In our examination, we have assumed the genuineness of all signatures, the authenticity and completeness of all documents submitted to us as originals, the conformity with the originals of all documents submitted to us as copies, the authenticity of the originals of such documents and the legal competence of all signatories to such documents. We have also assumed the authority of such persons signing on behalf of the parties thereto other than the Company and the due authorization, execution and delivery of all documents by the parties thereto other than the Company. We have assumed that the certificates representing the Securities have been properly authenticated by the signature of an authorized officer of the Company’s transfer agent. We have also assumed the conformity of the documents filed with the Commission via the Electronic Data Gathering, Analysis and Retrieval System (“EDGAR”), except for required EDGAR formatting changes, to physical copies submitted for our examination and the absence of any evidence extrinsic to the provisions of the written agreements between the parties that the parties intended a meaning contrary to that expressed by those provisions.

AUSTIN BEIJING BOSTON BRUSSELS HONG KONG LONDON LOS ANGELES NEW YORK PALO ALTO

SAN DIEGO SAN FRANCISCO SEATTLE SHANGHAI WASHINGTON, DC WILMINGTON, DE

RenovoRx, Inc.

November 10, 2022

Page 2

We express no opinion as to any matter relating to the laws of any jurisdiction other than the federal laws of the United States of America and the General Corporation Law of the State of Delaware and, solely as to the Warrants constituting legally binding obligations of the Company, the laws of the State of New York.

Based upon and subject to the foregoing qualifications, assumptions and limitations and the further limitations set out below, we are of the opinion that:

Our opinion that any document is legal, valid and binding is qualified as to:

This opinion is furnished to you in connection with the filing of the Registration Statement, and is not to be used, circulated, quoted or otherwise relied upon for any other purpose.

We hereby consent to the filing of this opinion as an exhibit to the Registration Statement, and to the use of our name wherever it appears in the Registration Statement, the prospectus forming part of the Registration Statement, any prospectus supplement, and in any amendment or supplement thereto. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.

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RenovoRx, Inc.

November 10, 2022

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Signature Page to the Legal Opinion